Transcriptional analysis of Lactobacillus brevis to N-butanol and ferulic acid stress responses.

ABSTRACT:

Background

The presence of anti-microbial phenolic compounds, such as the model compound ferulic acid, in biomass hydrolysates pose significant challenges to the widespread use of biomass in conjunction with whole cell biocatalysis or fermentation. Currently, these inhibitory compounds must be removed through additional downstream processing or sufficiently diluted to create environments suitable for most industrially important microbial strains. Simultaneously, product toxicity must also be overcome to allow for efficient production of next generation biofuels such as n-butanol, isopropanol, and others from these low cost feedstocks.

Methodology and principal findings

This study explores the high ferulic acid and n-butanol tolerance in Lactobacillus brevis, a lactic acid ba

SUBMITTER: Winkler J 

PROVIDER: S-EPMC3149049 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature