Quantitative time-course profiling of parasite and host cell proteins in the human malaria parasite Plasmodium falciparum.

ABSTRACT: Studies of the Plasmodium falciparum transcriptome have shown that the tightly controlled progression of the parasite through the intra-erythrocytic developmental cycle (IDC) is accompanied by a continuous gene expression cascade in which most expressed genes exhibit a single transcriptional peak. Because the biochemical and cellular functions of most genes are mediated by the encoded proteins, understanding the relationship between mRNA and protein levels is crucial for inferring biological activity from transcriptional gene expression data. Although studies on other organisms show that <50% of protein abundance variation may be attributable to corresponding mRNA levels, the situation in Plasmodium is further complicated by the dynamic nature of the cyclic gene expression cascade. In this

SUBMITTER: Foth BJ 

PROVIDER: S-EPMC3149090 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature