Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus.

ABSTRACT:

Background

Endothelial dysfunction contributes to the development of atherosclerosis in patients with diabetes mellitus, but the mechanisms of endothelial dysfunction in this setting are incompletely understood. Recent studies have shown altered mitochondrial dynamics in diabetes mellitus with increased mitochondrial fission and production of reactive oxygen species. We investigated the contribution of altered dynamics to endothelial dysfunction in diabetes mellitus.

Methods and results

We observed mitochondrial fragmentation (P=0.002) and increased expression of fission-1 protein (Fis1; P<0.0001) in venous endothelial cells freshly isolated from patients with diabetes mellitus (n=10) compared with healthy control subjects (n=9). In cultured human aortic endothelial cells ex

SUBMITTER: Shenouda SM 

PROVIDER: S-EPMC3149100 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature