Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation.

ABSTRACT: During mammalian oocyte maturation there are marked changes in the distribution of mitochondria that supply the majority of the cellular ATP. Such redistribution of mitochondria is critical for oocyte quality, as oocytes with a poor developmental potential display aberrant mitochondrial distribution and lower ATP levels. Here we have investigated the dynamics of mitochondrial ATP production throughout spontaneous mouse oocyte maturation, using live measurements of cytosolic and mitochondrial ATP levels. We have observed three distinct increases in cytosolic ATP levels temporally associated with discrete events of oocyte maturation. These changes in cytosolic ATP levels are mirrored by changes in mitochondrial ATP levels, suggesting that mitochondrial ATP production is stimulated during ooc

SUBMITTER: Yu Y 

PROVIDER: S-EPMC3149123 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature