Charged residues at protein interaction interfaces: unexpected conservation and orchestrated divergence.

ABSTRACT: Protein-protein interactions play an essential role in the functioning of cell. The importance of charged residues and their diverse role in protein-protein interactions have been well studied using experimental and computational methods. Often, charged residues located in protein interaction interfaces are conserved across the families of homologous proteins and protein complexes. However, on a large scale, it has been recently shown that charged residues are significantly less conserved than other residue types in protein interaction interfaces. The goal of this work is to understand the role of charged residues in the protein interaction interfaces through their conservation patterns. Here, we propose a simple approach where the structural conservation of the charged residue pairs is an

SUBMITTER: Zhao N 

PROVIDER: S-EPMC3149200 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature