Human linker histones: interplay between phosphorylation and O-β-GlcNAc to mediate chromatin structural modifications.

ABSTRACT: Eukaryotic chromatin is a combination of DNA and histone proteins. It is established fact that epigenetic mechanisms are associated with DNA and histones. Initial studies emphasize on core histones association with DNA, however later studies prove the importance of linker histone H1 epigenetic. There are many types of linker histone H1 found in mammals. These subtypes are cell specific and their amount in different types of cells varies as the cell functions. Many types of post-translational modifications which occur on different residues in each subtype of linker histone H1 induce conformational changes and allow the different subtypes of linker histone H1 to interact with chromatin at different stages during cell cycle which results in the regulation of transcription and gene expression.

SUBMITTER: Ahmad W 

PROVIDER: S-EPMC3149562 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature