Immunogenicity of autoantigens.

ABSTRACT:

Background

Autoantibodies against self-antigens have been associated not only with autoimmune diseases, but also with cancer and are even found in healthy individuals. The mechanism causing the autoantibody response remains elusive for the majority of the immunogenic antigens. To deepen the understanding of autoantibody responses, we ask whether natural-occurring, autoimmunity-associated and tumor-associated antigens have structural or biological features related to the immune response. To this end, we have carried out the most comprehensive in-silicio study of different groups of autoantigens including large antigen sets identified by our groups combined with publicly available antigen sets.

Results

We found evidence for an enrichment of genes with a larger exon length incr

SUBMITTER: Backes C 

PROVIDER: S-EPMC3149588 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature