Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood.

ABSTRACT:

Background

The effect of breast-feeding on the development of allergic disease is uncertain. There are no data that show whether this relationship varies by individual genotypes.

Objective

We sought to evaluate the effect of breast-feeding and gene-breast-feeding interactions on food sensitization (FS) in a prospective US birth cohort.

Methods

This study included 970 children who were prospectively followed since birth. Breast-feeding history was obtained from a standardized questionnaire interview. FS was defined as a specific IgE level of 0.35 kU(A)/L or greater to any of 8 common food allergens. Eighty-eight potentially functional single nucleotide polymorphisms (SNPs) were genotyped from 18 genes involved in innate immunity or T(H)1/T(H)2 balance. Logistic regress

SUBMITTER: Hong X 

PROVIDER: S-EPMC3149737 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature