Methyl-Analyzer--whole genome DNA methylation profiling.

ABSTRACT:

Summary

Methyl-Analyzer is a python package that analyzes genome-wide DNA methylation data produced by the Methyl-MAPS (methylation mapping analysis by paired-end sequencing) method. Methyl-MAPS is an enzymatic-based method that uses both methylation-sensitive and -dependent enzymes covering >80% of CpG dinucleotides within mammalian genomes. It combines enzymatic-based approaches with high-throughput next-generation sequencing technology to provide whole genome DNA methylation profiles. Methyl-Analyzer processes and integrates sequencing reads from methylated and unmethylated compartments and estimates CpG methylation probabilities at single base resolution.

Availability and implementation

Methyl-Analyzer is available at http://github.com/epigenomics/methylmaps. Sample data

SUBMITTER: Xin Y 

PROVIDER: S-EPMC3150045 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature