Maintenance therapy in advanced non-small cell lung cancer: evolution, tolerability and outcomes.

ABSTRACT: Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the industrialized world. Despite significant progress in early stage disease, survival rates for advanced disease remain low. Maintenance therapy is a treatment strategy that has been investigated extensively in NSCLC and has been the subject of considerable recent debate. Options for maintenance include continuing the initial combination chemotherapy regimen, continuing only single agent chemotherapy ('continuation maintenance') or introducing a new agent ('switch' maintenance therapy). Therapies that have been studied in this setting in randomized trials to date include chemotherapy, molecularly targeted agents and immunotherapy approaches. Following the development of multiple new agents that show activity in NS

SUBMITTER: Coate LE 

PROVIDER: S-EPMC3150062 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature