A protein thermometer controls temperature-dependent transcription of flagellar motility genes in Listeria monocytogenes.

ABSTRACT: Facultative bacterial pathogens must adapt to multiple stimuli to persist in the environment or establish infection within a host. Temperature is often utilized as a signal to control expression of virulence genes necessary for infection or genes required for persistence in the environment. However, very little is known about the molecular mechanisms that allow bacteria to adapt and respond to temperature fluctuations. Listeria monocytogenes (Lm) is a food-borne, facultative intracellular pathogen that uses flagellar motility to survive in the extracellular environment and to enhance initial invasion of host cells during infection. Upon entering the host, Lm represses transcription of flagellar motility genes in response to mammalian physiological temperature (37°C) with a concomitant temp

SUBMITTER: Kamp HD 

PROVIDER: S-EPMC3150276 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature