Phenosim--A software to simulate phenotypes for testing in genome-wide association studies.

ABSTRACT:

Background

There is a great interest in understanding the genetic architecture of complex traits in natural populations. Genome-wide association studies (GWAS) are becoming routine in human, animal and plant genetics to understand the connection between naturally occurring genotypic and phenotypic variation. Coalescent simulations are commonly used in population genetics to simulate genotypes under different parameters and demographic models.

Results

Here, we present phenosim, a software to add a phenotype to genotypes generated in time-efficient coalescent simulations. Both qualitative and quantitative phenotypes can be generated and it is possible to partition phenotypic variation between additive effects and epistatic interactions between causal variants. The output forma

SUBMITTER: Gunther T 

PROVIDER: S-EPMC3150295 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature