Extended interferon-alpha therapy accelerates telomere length loss in human peripheral blood T lymphocytes.

ABSTRACT:

Background

Type I interferons have pleiotropic effects on host cells, including inhibiting telomerase in lymphocytes and antiviral activity. We tested the hypothesis that long-term interferon treatment would result in significant reduction in average telomere length in peripheral blood T lymphocytes.

Methods/principal findings

Using a flow cytometry-based telomere length assay on peripheral blood mononuclear cell samples from the Hepatitis-C Antiviral Long-term Treatment against Cirrhosis (HALT-C) study, we measured T cell telomere lengths at screening and at months 21 and 45 in 29 Hepatitis-C virus infected subjects. These subjects had failed to achieve a sustained virologic response following 24 weeks of pegylated-interferon-alpha plus ribavirin treatment and were subseque

SUBMITTER: O'Bryan JM 

PROVIDER: S-EPMC3150344 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature