Modulation of androgen receptor signaling in hormonal therapy-resistant prostate cancer cell lines.

ABSTRACT:

Background

Prostate epithelial cells depend on androgens for survival and function. In (early) prostate cancer (PCa) androgens also regulate tumor growth, which is exploited by hormonal therapies in metastatic disease. The aim of the present study was to characterize the androgen receptor (AR) response in hormonal therapy-resistant PC346 cells and identify potential disease markers.

Methodology/principal findings

Human 19K oligoarrays were used to establish the androgen-regulated expression profile of androgen-responsive PC346C cells and its derivative therapy-resistant sublines: PC346DCC (vestigial AR levels), PC346Flu1 (AR overexpression) and PC346Flu2 (T877A AR mutation). In total, 107 transcripts were differentially-expressed in PC346C and derivatives after R1881 or hydr

SUBMITTER: Marques RB 

PROVIDER: S-EPMC3150397 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature