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Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

ABSTRACT: A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).

SUBMITTER: Liu X 

PROVIDER: S-EPMC3150510 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

Liu Xiangdong X   Invernizzi Pietro P   Lu Yue Y   Kosoy Roman R   Lu Yan Y   Bianchi Ilaria I   Podda Mauro M   Xu Chun C   Xie Gang G   Macciardi Fabio F   Selmi Carlo C   Lupoli Sara S   Shigeta Russell R   Ransom Michael M   Lleo Ana A   Lee Annette T AT   Mason Andrew L AL   Myers Robert P RP   Peltekian Kevork M KM   Ghent Cameron N CN   Bernuzzi Francesca F   Zuin Massimo M   Rosina Floriano F   Borghesio Elisabetta E   Floreani Annarosa A   Lazzari Roberta R   Niro Grazia G   Andriulli Angelo A   Muratori Luigi L   Muratori Paolo P   Almasio Piero L PL   Andreone Pietro P   Margotti Marzia M   Brunetto Maurizia M   Coco Barbara B   Alvaro Domenico D   Bragazzi Maria C MC   Marra Fabio F   Pisano Alessandro A   Rigamonti Cristina C   Colombo Massimo M   Marzioni Marco M   Benedetti Antonio A   Fabris Luca L   Strazzabosco Mario M   Portincasa Piero P   Palmieri Vincenzo O VO   Tiribelli Claudio C   Croce Lory L   Bruno Savino S   Rossi Sonia S   Vinci Maria M   Prisco Cleofe C   Mattalia Alberto A   Toniutto Pierluigi P   Picciotto Antonio A   Galli Andrea A   Ferrari Carlo C   Ferrari Carlo C   Colombo Silvia S   Casella Giovanni G   Morini Lorenzo L   Caporaso Nicola N   Colli Agostino A   Spinzi Giancarlo G   Montanari Renzo R   Gregersen Peter K PK   Heathcote E Jenny EJ   Hirschfield Gideon M GM   Siminovitch Katherine A KA   Amos Christopher I CI   Gershwin M Eric ME   Seldin Michael F MF  

Nature genetics 20100718 8

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38). ...[more]

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