Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population.

ABSTRACT:

Objective

To date, CCR5 variants remain the only human genetic factors to be confirmed to impact HIV-1 acquisition. However, protective CCR5 variants are largely absent in African populations, in which sporadic resistance to HIV-1 infection is still unexplained. We investigated whether common genetic variants associate with HIV-1 susceptibility in Africans.

Methods

We performed a genome-wide association study (GWAS) in a population of 1532 individuals from Malawi, a country with high prevalence of HIV-1 infection. Using single-nucleotide polymorphisms (SNPs) present on the genome-wide chip, we also investigated previously reported associations with HIV-1 susceptibility or acquisition. Recruitment was coordinated by the Center for HIV/AIDS Vaccine Immunology at two sexually t

SUBMITTER: Petrovski S 

PROVIDER: S-EPMC3150594 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature