Associations of nicotine intake measures with CHRN genes in Finnish smokers.

ABSTRACT:

Introduction

Genetic effects contribute to individual differences in smoking behavior. Persistence to smoke despite known harmful health effects is mostly driven by nicotine addiction. As the physiological effects of nicotine are mediated by nicotinic acetylcholine receptors (nAChRs), we aimed at examining whether single nucleotide polymorphisms (SNPs) residing in nAChR subunit (CHRN) genes, other than CHRNA3/CHRNA5/CHRNB4 gene cluster previously showing association in our sample, are associated with smoking quantity or serum cotinine levels.

Methods

The study sample consisted of 485 Finnish adult daily smokers (age 30-75 years, 59% men) assessed for the number of cigarettes smoked per day (CPD) and serum cotinine level. We first studied SNPs residing on selected nAChR subun

SUBMITTER: Keskitalo-Vuokko K 

PROVIDER: S-EPMC3150688 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature