Nuclear receptor coactivators are coexpressed with steroid receptors and regulated by estradiol in mouse brain.

ABSTRACT:

Background/aims

The steroid hormones, including estradiol (E) and progesterone, act in the brain to regulate female reproductive behavior and physiology. These hormones mediate many of their biological effects by binding to their respective intracellular receptors. The receptors for estrogens (ER) and progestins (PR) interact with nuclear receptor coactivators to initiate transcription of steroid-responsive genes. Work from our laboratory and others reveals that nuclear receptor coactivators, including steroid receptor coactivator-1 (SRC-1) and SRC-2, function in brain to modulate ER-mediated induction of the PR gene and hormone-dependent behaviors. In order for steroid receptors and coactivators to function together, both must be expressed in the same cells.

Methods

Triple-

SUBMITTER: Tognoni CM 

PROVIDER: S-EPMC3150972 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature