The genetics of common variation affecting platelet development, function and pharmaceutical targeting.

ABSTRACT: Common variant effects on human platelet function and response to anti-platelet treatment have traditionally been studied using candidate gene approaches involving a limited number of variants and genes. These studies have often been undertaken in clinically defined cohorts. More recently, studies have applied genome-wide scans in larger population samples than prior candidate studies, in some cases scanning relatively healthy individuals. These studies demonstrate synergy with some prior candidate gene findings (e.g., GP6, ADRA2A) but also uncover novel loci involved in platelet function. Here, I summarise findings on common genetic variation influencing platelet development, function and therapeutics. Taken together, candidate gene and genome-wide studies begin to account for common vari

SUBMITTER: Johnson AD 

PROVIDER: S-EPMC3151008 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature