Nanoscale studies of protein-membrane interactions in blood clotting.

ABSTRACT: Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.

SUBMITTER: Morrissey JH 

PROVIDER: S-EPMC3151027 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature