Caenorhabditis elegans evolves a new architecture for the multi-aminoacyl-tRNA synthetase complex.

ABSTRACT: MARS is an evolutionary conserved supramolecular assembly of aminoacyl-tRNA synthetases found in eukaryotes. This complex was thought to be ubiquitous in the deuterostome and protostome clades of bilaterians because similar complexes were isolated from arthropods and vertebrates. However, several features of the component enzymes suggested that in the nematode Caenorhabditis elegans, a species grouped with arthropods in modern phylogeny, this complex might not exist, or should display a significantly different structural organization. C. elegans was also taken as a model system to study in a multicellular organism amenable to experimental approaches, the reason for existence of these supramolecular entities. Here, using a proteomic approach, we have characterized the components of MARS in

SUBMITTER: Havrylenko S 

PROVIDER: S-EPMC3151090 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature