HIV pre-exposure prophylaxis (PrEP)--a quantitative ethics appraisal.

ABSTRACT:

Background

There is now strong evidence that preventive oral antiretroviral therapy can moderately reduce likelihood of HIV infection. This concept is called HIV pre-exposure prophylaxis (PrEP). Premature closures of some previous PrEP clinical trials, secondary to ethical concerns, did not stop research. We aimed to appraise the extent of ethics considerations reporting in PrEP study documents.

Methods

We conducted a systematic quantitative ethics appraisal, grounded in PrEP literature and using eight principles proposed by Ezechiel Emanuel. We developed an a priori checklist of 101 evidence-based ethics items. We obtained protocols for eleven of nineteen clinical controlled studies identified. Two reviewers independently appraised study documents against the checklist. Eth

SUBMITTER: Kokolo MB 

PROVIDER: S-EPMC3151244 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature