Repeated labilization-reconsolidation processes strengthen declarative memory in humans.

ABSTRACT: The idea that memories are immutable after consolidation has been challenged. Several reports have shown that after the presentation of a specific reminder, reactivated old memories become labile and again susceptible to amnesic agents. Such vulnerability diminishes with the progress of time and implies a re-stabilization phase, usually referred to as reconsolidation. To date, the main findings describe the mechanisms associated with the labilization-reconsolidation process, but little is known about its functionality from a biological standpoint. Indeed, two functions have been proposed. One suggests that destabilization of the original memory after the reminder allows the integration of new information into the background of the original memory (memory updating), and the other suggests t

SUBMITTER: Forcato C 

PROVIDER: S-EPMC3151295 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature