Normative data and validation of a regression based summary score for assessing meaningful neuropsychological change.

ABSTRACT: Reliable detection and quantification of longitudinal cognitive change are of considerable importance in many neurological disorders, particularly to monitor central nervous system effects of disease progression and treatment. In the current study, we developed normative data for repeated neuropsychological (NP) assessments (6 testings) using a modified standard regression-based (SRB) approach in a sample that includes both HIV-uninfected (HIV-, N = 172) and neuromedically stable HIV-infected (HIV+, N = 124) individuals. Prior analyses indicated no differences in NP change between the infected and uninfected participants. The norms for change included correction for factors found to significantly affect follow-up performance, using hierarchical regression. The most robust and consistent pr

SUBMITTER: Cysique LA 

PROVIDER: S-EPMC3151558 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature