Crosstalk between c-Jun and TAp73alpha/beta contributes to the apoptosis-survival balance.

ABSTRACT: The p53-family member p73 plays a role in various cellular signaling pathways during development and growth control and it can have tumor suppressor properties. Several isoforms of p73 exist with considerable differences in their function. Whereas the functions of the N-terminal isoforms (TA and ΔNp73) and their opposing pro- and antiapoptotic roles have become evident, the functional differences of the distinct C-terminal splice forms of TAp73 have remained unclear. Here, we characterized the global genomic binding sites for TAp73α and TAp73β by chromatin immunoprecipitation sequencing as well as the transcriptional responses by performing RNA sequencing. We identified a specific p73 consensus binding motif and found a strong enrichment of AP1 motifs in close proximity to binding sites fo

SUBMITTER: Koeppel M 

PROVIDER: S-EPMC3152320 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature