Specialization versus adaptation: two strategies employed by cyanophages to enhance their translation efficiencies.

ABSTRACT: Effective translation of the viral genome during the infection cycle most likely enhances its fitness. In this study, we reveal two different strategies employed by cyanophages, viruses infecting cyanobacteria, to enhance their translation efficiency. Cyanophages of the T7-like Podoviridae family adjust their GC content and codon usage to those of their hosts. In contrast, cyanophages of the T4-like Myoviridae family maintain genomes with low GC content, thus sometimes differing from that of their hosts. By introducing their own specific set of tRNAs, they appear to modulate the tRNA pools of hosts with tRNAs that fit the viral low GC preferred codons. We assessed the possible effects of those viral tRNAs on cyanophages and cyanobacterial genomes using the tRNA adaptation index, which meas

SUBMITTER: Limor-Waisberg K 

PROVIDER: S-EPMC3152331 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature