A selective sweep of >8 Mb on chromosome 26 in the Boxer genome.

ABSTRACT:

Background

Modern dog breeds display traits that are either breed-specific or shared by a few breeds as a result of genetic bottlenecks during the breed creation process and artificial selection for breed standards. Selective sweeps in the genome result from strong selection and can be detected as a reduction or elimination of polymorphism in a given region of the genome.

Results

Extended regions of homozygosity, indicative of selective sweeps, were identified in a genome-wide scan dataset of 25 Boxers from the United Kingdom genotyped at ~20,000 single-nucleotide polymorphisms (SNPs). These regions were further examined in a second dataset of Boxers collected from a different geographical location and genotyped using higher density SNP arrays (~170,000 SNPs). A selective sw

SUBMITTER: Quilez J 

PROVIDER: S-EPMC3152542 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature