Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades.

ABSTRACT: The aryl hydrocarbon receptor (AHR) and hypoxia inducible factors (HIFs) are transcription factors that control the adaptive response to toxicants such as dioxins and decreases in available oxygen, respectively. The AHR and HIFs utilize the same heterodimeric partner, the aryl hydrocarbon nuclear translocator (ARNT) for proper function. This requirement raises the possibility that cross-talk exists between these critical signaling systems. Single gene and reporter assays have yielded conflicting results regarding the nature of the competition for ARNT. Therefore, to determine the extent of cross-talk between the AHR and HIFs, a comprehensive analysis was performed using global gene expression analysis. The results identified 767 and 430 transcripts that are sensitive to cobalt chloride and

SUBMITTER: Lee K A 

PROVIDER: S-EPMC3152583 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature