Ontology highlight
ABSTRACT:
SUBMITTER: Prensner JR
PROVIDER: S-EPMC3152676 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Nature biotechnology 20110731 8
Noncoding RNAs (ncRNAs) are emerging as key molecules in human cancer, with the potential to serve as novel markers of disease and to reveal uncharacterized aspects of tumor biology. Here we discover 121 unannotated prostate cancer-associated ncRNA transcripts (PCATs) by ab initio assembly of high-throughput sequencing of polyA(+) RNA (RNA-Seq) from a cohort of 102 prostate tissues and cells lines. We characterized one ncRNA, PCAT-1, as a prostate-specific regulator of cell proliferation and sho ...[more]