Assessment of pharmacologic area under the curve when baselines are variable.

ABSTRACT:

Purpose

The area under the curve (AUC) is commonly used to assess the extent of exposure of a drug. The same concept can be applied to generally assess pharmacodynamic responses and the deviation of a signal from its baseline value. When the initial condition for the response of interest is not zero, there is uncertainty in the true value of the baseline measurement. This necessitates the consideration of the AUC relative to baseline to account for this inherent uncertainty and variability in baseline measurements.

Methods

An algorithm to calculate the AUC with respect to a variable baseline is developed by comparing the AUC of the response curve with the AUC of the baseline while taking into account uncertainty in both measurements. Furthermore, positive and negative compon

SUBMITTER: Scheff JD 

PROVIDER: S-EPMC3152796 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature