A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex.

ABSTRACT:

Background

Bacterial division is produced by the formation of a macromolecular complex in the middle of the cell, called the divisome, formed by more than 10 proteins. This process can be divided into two steps, in which the first is the polymerization of FtsZ to form the Z ring in the cytoplasm, and then the sequential addition of FtsA/ZipA to anchor the ring at the cytoplasmic membrane, a stage completed by FtsEX and FtsK. In the second step, the formation of the peptidoglycan synthesis machinery in the periplasm takes place, followed by cell division. The proteins involved in connecting both steps in cell division are FtsQ, FtsB and FtsL, and their interaction is a crucial and conserved event in the division of different bacteria. These components are small bitopic membrane prot

SUBMITTER: Villanelo F 

PROVIDER: S-EPMC3152878 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature