A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle.

ABSTRACT:

Background

Mitochondria are a vital component of eukaryotic cells and their dysfunction is implicated in a large number of metabolic, degenerative and age-related human diseases. The mechanism or these disorders can be difficult to elucidate due to the inherent complexity of mitochondrial metabolism. To understand how mitochondrial metabolic dysfunction contributes to these diseases, a metabolic model of a human heart mitochondrion was created.

Results

A new model of mitochondrial metabolism was built on the principle of metabolite availability using MitoMiner, a mitochondrial proteomics database, to evaluate the subcellular localisation of reactions that have evidence for mitochondrial localisation. Extensive curation and manual refinement was used to create a model called

SUBMITTER: Smith AC 

PROVIDER: S-EPMC3152903 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature