An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration.

ABSTRACT: Skeletal muscle tissue provides mechanical force for locomotion of all vertebrate animals. It is prone to damage from acute physical trauma and physiological stress. To cope with this, it possesses a tremendous capacity for rapid and effective repair that is widely held to be accomplished by the satellite cells lying between the muscle fiber plasmalemma and the basement membrane. Cell transplantation and lineage-tracing studies have demonstrated that Pax7-expressing (Pax7(+)) satellite cells can repair damaged muscle tissue repeatedly after several bouts of acute injury. These findings provided evidence that Pax7(+) cells are muscle stem cells. However, stem cells from a variety of other origins are also reported to contribute to myofibers upon engraftment into muscles, questioning whether

SUBMITTER: Lepper C 

PROVIDER: S-EPMC3152922 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature