CD28 expressed on malignant plasma cells induces a prosurvival and immunosuppressive microenvironment.

ABSTRACT: Interactions between the malignant plasma cells of multiple myeloma and stromal cells within the bone marrow microenvironment are essential for myeloma cell survival, mirroring the same dependence of normal bone marrow-resident long-lived plasma cells on specific marrow niches. These interactions directly transduce prosurvival signals to the myeloma cells and also induce niche production of supportive soluble factors. However, despite their central importance, the specific molecular and cellular components involved remain poorly characterized. We now report that the prototypic T cell costimulatory receptor CD28 is overexpressed on myeloma cells during disease progression and in the poor-prognosis subgroups and plays a previously unrecognized role as a two-way molecular bridge to support my

SUBMITTER: Nair JR 

PROVIDER: S-EPMC3152989 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature