APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study.

ABSTRACT:

Background

Carriers of APOE ε2 and ε4 have an increased risk of intracerebral haemorrhage (ICH) in lobar regions, presumably because of the effects of these gene variants on risk of cerebral amyloid angiopathy. We aimed to assess whether these variants also associate with severity of ICH, in terms of haematoma volume at presentation and subsequent outcome.

Methods

We investigated the association of APOE ε2 and ε4 with ICH volume and outcomes in patients with primary ICH in three phases: a discovery phase of 865 individuals of European ancestry from the Genetics of Cerebral Hemorrhage on Anticoagulation study, and replication phases of 946 Europeans (replication 1) and 214 African-Americans (replication 2) from an additional six studies. We also assessed the association of AP

SUBMITTER: Biffi A 

PROVIDER: S-EPMC3153411 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature