Incidental findings on brain magnetic resonance imaging of children with sickle cell disease.

ABSTRACT:

Objective

We describe the prevalence and range of incidental intracranial abnormalities identified through MRI of the brain in a large group of children screened for a clinical trial.

Methods

We included 953 children between 5 and 14 years of age who were screened with MRI of the brain for the Silent Infarct Transfusion Trial. All had sickle cell anemia or sickle beta-null thalassemia. MRI scans were interpreted by 3 neuroradiologists. MRI scans reported to have any abnormality were reviewed by 2 study neuroradiologists. Incidental findings were classified into 4 categories, that is, no, routine, urgent, or immediate referral recommended. Cerebral infarctions and vascular lesions were not considered incidental and were excluded.

Results

We identified 63 children (6.6%

SUBMITTER: Jordan LC 

PROVIDER: S-EPMC3153884 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature