Lipoprotein subclass abnormalities and incident hypertension in initially healthy women.

ABSTRACT:

Background

Abnormalities in traditional lipids, particularly decreased HDL cholesterol and increased triglycerides, can precede the onset of hypertension. Whether lipoprotein particle size or subclass concentrations play a role in the development of hypertension is unknown.

Methods

We followed 17 527 initially healthy women without baseline hypertension prospectively for 8 years. At baseline, information regarding traditional lipids and hypertension risk factors was obtained, and lipoprotein size and subclass concentrations were measured by nuclear magnetic resonance spectroscopy.

Results

Baseline lipoprotein size and subclass concentrations were significantly associated with incident hypertension. Although LDL cholesterol was not associated with hypertension [odds ra

SUBMITTER: Paynter NP 

PROVIDER: S-EPMC3153909 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature