Statistical power and estimation of incidence rate ratios obtained from BED incidence testing for evaluating HIV interventions among young people.

ABSTRACT:

Background

The objectives of this study were to determine the capacity of BED incidence testing to a) estimate the effect of a HIV prevention intervention and b) provide adequate statistical power, when used among young people from sub-Saharan African settings with high HIV incidence rates.

Methods

Firstly, after having elaborated plausible scenarios based on empirical data and the characteristics of the BED HIV-1 Capture EIA (BED) assay, we conducted statistical calculations to determine the BED theoretical power and HIV incidence rate ratio (IRR) associated with an intervention when using BED incidence testing. Secondly, we simulated a cross-sectional study conducted in a population among whom an HIV intervention was rolled out. Simulated data were analyzed using a log-lin

SUBMITTER: Auvert B 

PROVIDER: S-EPMC3154202 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature