Reporting FDR analogous confidence intervals for the log fold change of differentially expressed genes.

ABSTRACT:

Background

Gene expression experiments are common in molecular biology, for example in order to identify genes which play a certain role in a specified biological framework. For that purpose expression levels of several thousand genes are measured simultaneously using DNA microarrays. Comparing two distinct groups of tissue samples to detect those genes which are differentially expressed one statistical test per gene is performed, and resulting p-values are adjusted to control the false discovery rate. In addition, the expression change of each gene is quantified by some effect measure, typically the log fold change. In certain cases, however, a gene with a significant p-value can have a rather small fold change while in other cases a non-significant gene can have a rather large fo

SUBMITTER: Jung K 

PROVIDER: S-EPMC3154206 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature