RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis.

ABSTRACT:

Background

The absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosis as well as lack of lasting memory responses are some of the major causes attributed to the non effectiveness of Bacille Calmette-Gue'rin (BCG) vaccine. Immunization schedules addressing these issues can offer better strategy for protection against tuberculosis.

Methods

The immunological responses evoked upon administration of archaeosome based antigen delivery system comprising T cell antigen, Rv3619c (an ESAT-6 family protein), has been assessed against experimental murine tuberculosis in BALB/c mice.

Results

Archaeosome based subunit vaccine has been found to elicit type-1 cytokines in the immunized mice. Besides effective T cell memory respo

SUBMITTER: Ansari MA 

PROVIDER: S-EPMC3154911 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature