Calculation of the relative chemical stabilities of proteins as a function of temperature and redox chemistry in a hot spring.

ABSTRACT: Uncovering the chemical and physical links between natural environments and microbial communities is becoming increasingly amenable owing to geochemical observations and metagenomic sequencing. At the hot spring known as Bison Pool in Yellowstone National Park, the cooling of the water in the outflow channel is associated with an increase in oxidation potential estimated from multiple field-based measurements. Representative groups of proteins whose sequences were derived from metagenomic data also exhibit an increase in average oxidation state of carbon in the protein molecules with distance from the hot-spring source. The energetic requirements of reactions to form selected proteins used in the model were computed using amino-acid group additivity for the standard molal thermodynamic pro

SUBMITTER: Dick JM 

PROVIDER: S-EPMC3154912 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature