Discovery of sexual dimorphisms in metabolic and genetic biomarkers.

ABSTRACT: Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level. Serum metabolite concentrations allow a direct readout of biological processes, and association of specific metabolomic signatures with complex diseases such as Alzheimer's disease and cardiovascular and metabolic disorders has been shown. There are well-known correlations between sex and the incidence, prevalence, age of onset, symptoms, and severity of a disease, as well as the reaction to drugs. However, most of the studies published so far did not consider the role of sexual dimorphism and did not analyse their data stratified by gender. This stu

SUBMITTER: Mittelstrass K 

PROVIDER: S-EPMC3154959 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature