Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.

ABSTRACT: Although significant variations in the metabolic profiles exist among different cells, little is understood in terms of genetic regulations of such cell type-specific metabolic phenotypes and nutrient requirements. While many cancer cells depend on exogenous glutamine for survival to justify the therapeutic targeting of glutamine metabolism, the mechanisms of glutamine dependence and likely response and resistance of such glutamine-targeting strategies among cancers are largely unknown. In this study, we have found a systematic variation in the glutamine dependence among breast tumor subtypes associated with mammary differentiation: basal- but not luminal-type breast cells are more glutamine-dependent and may be susceptible to glutamine-targeting therapeutics. Glutamine independence of lum

SUBMITTER: Kung HN 

PROVIDER: S-EPMC3154963 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature