Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics.

ABSTRACT: Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/β-turn/sheet motif.

SUBMITTER: Raghuraman A 

PROVIDER: S-EPMC3154983 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature