Total synthesis of (±)-cortistatin J from furan.

ABSTRACT: A concise, diastereoselective total synthesis of (±)-cortistatin J has been completed in 20 steps from furan. Key steps include an intramolecular [4 + 3] cyclization of a disubstituted furan with a (Z)-2-(trialkylsilyloxy)-2-enal to construct the tetracyclic core and a (Z)-vinylsilane/iminium ion cyclization to form the A ring.

SUBMITTER: Nilson MG 

PROVIDER: S-EPMC3154988 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature