Protein functional links in Trypanosoma brucei, identified by gene fusion analysis.

ABSTRACT:

Background

Domain or gene fusion analysis is a bioinformatics method for detecting gene fusions in one organism by comparing its genome to that of other organisms. The occurrence of gene fusions suggests that the two original genes that participated in the fusion are functionally linked, i.e. their gene products interact either as part of a multi-subunit protein complex, or in a metabolic pathway. Gene fusion analysis has been used to identify protein functional links in prokaryotes as well as in eukaryotic model organisms, such as yeast and Drosophila.

Results

In this study we have extended this approach to include a number of recently sequenced protists, four of which are pathogenic, to identify fusion linked proteins in Trypanosoma brucei, the causative agent of African s

SUBMITTER: Dimitriadis D 

PROVIDER: S-EPMC3155505 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature