Single-monomer formulation of polymerized polyethylene glycol diacrylate as a nonadsorptive material for microfluidics.

ABSTRACT: Nonspecific adsorption in microfluidic systems can deplete target molecules in solution and prevent analytes, especially those at low concentrations, from reaching the detector. Polydimethylsiloxane (PDMS) is a widely used material for microfluidics, but it is prone to nonspecific adsorption, necessitating complex chemical modification processes to address this issue. An alternative material to PDMS that does not require subsequent chemical modification is presented here. Poly(ethylene glycol) diacrylate (PEGDA) mixed with photoinitiator forms on exposure to ultraviolet (UV) radiation a polymer with inherent resistance to nonspecific adsorption. Optimization of the polymerized PEGDA (poly-PEGDA) formula imbues this material with some of the same properties, including optical clarity, water

SUBMITTER: Rogers CI 

PROVIDER: S-EPMC3155648 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature