Comparative genomics of Escherichia coli isolated from patients with inflammatory bowel disease.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is used to describe a state of idiopathic, chronic inflammation of the gastrointestinal tract. The two main phenotypes of IBD are Crohn's disease (CD) and ulcerative colitis (UC). The major cause of IBD-associated mortality is colorectal cancer. Although both host-genetic and exogenous factors have been found to be involved, the aetiology of IBD is still not well understood. In this study we characterized thirteen Escherichia coli strains from patients with IBD by comparative genomic hybridization employing a microarray based on 31 sequenced E. coli genomes from a wide range of commensal and pathogenic isolates.

Results

The IBD isolates, obtained from patients with UC and CD, displayed remarkably heterogeneous genomic profiles with

SUBMITTER: Vejborg RM 

PROVIDER: S-EPMC3155842 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature