The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial.

ABSTRACT:

Background

Despite the reported benefits, weight loss is not always advised for older adults because some observational studies have associated weight loss with increased mortality. However, the distinction between intentional and unintentional weight loss is difficult to make in an observational context, so the effect of intentional weight loss on mortality may be clarified in the setting of a randomized controlled trial.

Objective

The objective was to determine the effect of intentional weight loss on all-cause mortality by using follow-up data from a randomized trial completed in 1995 that included a weight-loss arm.

Design

The Trial of Nonpharmacologic Intervention in the Elderly (TONE) used a 2 × 2 factorial design to determine the effect of dietary weight loss,

SUBMITTER: Shea MK 

PROVIDER: S-EPMC3155925 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature