Hyaloperonospora arabidopsidis ATR1 effector is a repeat protein with distributed recognition surfaces.

ABSTRACT: The in planta association of the Hyaloperonospora arabidopsidis effector ATR1 with the cognate Arabidopsis thaliana RPP1 immune receptor activates a disease-resistance signaling pathway that inhibits pathogen growth. To define the molecular events specifying effector recognition by RPP1, we determined the crystal structure of ATR1 and assayed in planta the effects of surface polymorphisms that are critical to activating plant immunity. ATR1 adopts an elongated, all-helical, two-domain, seahorse-like structure with an overall architecture unlike any previously described fold. Structural comparisons highlight a tandemly duplicated, five-helix motif in the C-terminal domain that creates a structural framework for rapid diversification. Identification and mapping of critical recognition sites

SUBMITTER: Chou S 

PROVIDER: S-EPMC3156156 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature